Physiological stresses related to hypercapnia during patrols on submarines.

Physiological studies on hypercapnic effects carried out on 13 Polaris patrols are summarized. The average CO2 concentrations ranged from 0.7-1% CO2; CO2 was identified as the only environmental contaminant of the submarine atmosphere that has a direct effect on respiration in the concentration range found in the submarine atmosphere. A comparison has been made of physiological effects produced during 42 days of exposure to 1.5% CO2 during laboratory studies (L.S.) with those observed during 50 to 60 days of exposure to 0.7-1% CO2 on patrols (P.S.). A close similarity was found in the effects on respiration and blood electrolytes under both conditions. Respiratory minute volume was elevated by 50-63% because of increased tidal volume. The physiological dead space increased 60%. Vital capacity showed a trend toward a decrease. Studies of acid-base balance carried out during patrols demonstrated cyclic changes in blood pH and bicarbonate; pH and blood bicarbonate fell during the first 17 days of exposure, rose during the subsequent 20 days, and decreased again after 40 days. These cycles cannot be explained on the basis of known renal regulations in CO2-induced acidosis and were not found during exposure to 1.5% CO2. The hypothesis is advanced that these changes in acid-base balance are caused by cycles in CO2 uptake and release in bones. The time constants of the bond CO2 stores fit the observed length of cycles in acid-base balance. Correlation with cycles of calcium metabolism provides further support for this hypothesis. Red cell electrolytes showed similar changes under 1.5% CO2 (L.S.) and 0.7-1% CO2 (P.S.). Red cell sodium increased and potassium decreased. Moreover, red cell calcium also increased under both conditions. The significance of these red cell electrolyte changes in regard to changes in permeability and active transport remains to be clarified. An increased gastric acidity was found during patrol (exposure to 0.8-0.95% CO2). The changes observed during patrols disappeared during the recovery periods.